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Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory Oztop, Baris
Abstract
The free energy functional theory of protein folding presents a framework to explain the effects of heterogeneity in the folding mechanism. These heterogeneity effects introduce changes in the folding free energy barriers that govern the rates for 2-state folding proteins. Here in this thesis, we focused on checking the validity of the predictions of free energy functional theory by using the data from simulations of Cα , Gō proteins and from experiments. Our results show that folding rates correlate with the degree of heterogeneity in the formation of native contacts for both simulated structures and real proteins.
Item Metadata
| Title |
Heterogeneity of the folding mechanism : testing the predictions of free energy functional theory
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| Creator | |
| Publisher |
University of British Columbia
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| Date Issued |
2004
|
| Description |
The free energy functional theory of protein folding presents a framework to
explain the effects of heterogeneity in the folding mechanism. These heterogeneity
effects introduce changes in the folding free energy barriers that govern
the rates for 2-state folding proteins. Here in this thesis, we focused on checking
the validity of the predictions of free energy functional theory by using the data
from simulations of Cα , Gō proteins and from experiments. Our results show
that folding rates correlate with the degree of heterogeneity in the formation of
native contacts for both simulated structures and real proteins.
|
| Extent |
2228173 bytes
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| Genre | |
| Type | |
| File Format |
application/pdf
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| Language |
eng
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| Date Available |
2009-11-24
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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| DOI |
10.14288/1.0085149
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| URI | |
| Degree | |
| Program | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
2004-05
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| Campus | |
| Scholarly Level |
Graduate
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| Aggregated Source Repository |
DSpace
|
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Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.