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UBC Theses and Dissertations

Dental management of herpes simplex virus (HSV-1 & HSV-2) using n-butyl and 2-octyl cyanoacrylate as a barrier : a pilot study Lan, Yolanda Haruka


Objectives: Herpes simplex virus (HSV-1, 2) can present as symptomatic oral lesions or asymptomatic shedding. The risk of viral spreading during dental procedures is a safety concern, which we hypothesized may be reduced using cyanoacrylate adhesive (CA). The study aimed to determine 1) the magnitude of asymptomatic reactivation compared to symptomatic and 2) the efficacy of CA in limiting the virus transmission in symptomatic oral lesions. Methods: Thirty-three participants were recruited from UBC-Faculty of Dentistry. Oral mucosal (OS) and lesion swabs (LS) were collected and tested for HSV-1 and 2 using polymerase chain reaction (PCR) assay. Asymptomatic participants with possible history of oral HSV lesions (n=17) were followed for three months. Symptomatic lesions (n=11) had OS and LS collected, CA applied and subjected to soft tissue manipulation (STM). CA’s efficacy to alleviate/cause pain was assessed by daily journaling using visual analogue scale (VAS: 0-10). Examiner was blinded to symptomatic LS results and statistical analyses were performed using SPSS 27. Results: Twenty-one participants completed the study. One case of asymptomatic reactivation was detected out of 17 asymptomatic participants (2.0% reactivation rate). Data on 11 lesions were collected. Correlations between various lesion clinical parameters were assessed. Both lesion size and lesion PCR cycle threshold value (Ct) (p=0.04) and lesion day and stage (p

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