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UBC Theses and Dissertations

Investigation of Parkinson's disease related pattern and altered dopamine release pattern in treatment-induced complications and non-motor symptoms of Parkinson's disease Fu, Jessie FangLu

Abstract

Parkinson's Disease is the second most common neurodegenerative disorder. Apart from motor symptoms, cognitive deficits are also common. Treatments, mainly in the form of dopamine (DA) replacement therapy, although reduce motor symptoms at first, can lead to treatment-induced complications. Abnormal spatial covariance metabolic pattern linked to the motor and cognitive symptoms of Parkinson's Disease (PD) have previously been defined using Fludeoxyglucose (FDG) Positron Emission Tomography (PET). In contrast, little is known about the functional networks in the serotonergic system, which is known to be closely related to cognitive dysfunctions of the disease. In this thesis work, we want to investigate the interactions between the dopaminergic and serotonergic pathways in presymptomatic and early stages of the disease, and their contributions to treatment-induced complications and non-motor symptoms in PD subjects. In the first part of this project, we investigated the PD and LRRK2 mutation related patterns in the serotonergic system by studying 12 asymptomatic LRRK2 mutation carriers (LRRK2-AMC), 9 healthy controls (HC), and 18 PD subjects using [¹¹C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile (DASB) PET and a principal component analysis (PCA) based regional covariance model with bootstrap resampling. The serotonergic PD-related pattern (SPDRP) significantly separated PD subjects from HC subjects (p

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