The Open Collections website will be undergoing maintenance on Wednesday December 7th from 9pm to 11pm PST. The site may be temporarily unavailable during this time.

UBC Theses and Dissertations

UBC Theses Logo

UBC Theses and Dissertations

Spatial stochastic models of HSV-2 lesion dynamics and their link with HIV-1 acquisition Byrne, Catherine Margaret McCombe

Abstract

Patients with Herpes Simplex Virus-2 (HSV-2) infection face a significantly higher risk of contracting HIV-1. This marked increase is thought to be due not only to herpetic lesions serving as an entry point for the HIV-1 virus, but also to the increase in CD4+ T cells in the human genital mucosa during HSV-2 lesional events. By creating a stochastic, spatial, mathematical model describing the behaviour of the HSV-2 infection and immune response in the genital mucosa, I first capture the dynamics that occur during the development of an HSV-2 lesion. I then use this model to quantify the risk of acquiring HIV-1 in HSV-2 positive patients upon sexual exposure, and determine whether antivirals meant to control HSV-2 can decrease HIV-1 infectivity. While theory predicts that HSV-2 treatment should lower HIV-1 infection probability, my results show that this may not be the case unless a critical dosage of HSV-2 treatment is given to the patient. These results help to explain the conflicting data on HIV-1 infection probability in HSV-2 patients and allow for further insight into the type of treatment HSV-2 positive patients should receive to prevent HIV-1 infection.

Item Citations and Data

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International