Spatial stochastic models of HSV-2 lesion dynamics and their link with HIV-1 acquisition
department or school: Science, Faculty of
department or school: Mathematics, Department of
data provider: DSpace
degree campus: UBCV
creator: Byrne, Catherine Margaret McCombe
issued: 2016-07-14T20:02:13Z
issued: 2016
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Patients with Herpes Simplex Virus-2 (HSV-2) infection face a significantly higher risk of contracting HIV-1. This marked increase is thought to be due not only to herpetic lesions serving as an entry point for the HIV-1 virus, but also to the increase in CD4+ T cells in the human genital mucosa during HSV-2 lesional events. By creating a stochastic, spatial, mathematical model describing the behaviour of the HSV-2 infection and immune response in the genital mucosa, I first capture the dynamics that occur during the development of an HSV-2 lesion. I then use this model to quantify the risk of acquiring HIV-1 in HSV-2 positive patients upon sexual exposure, and determine whether antivirals meant to control HSV-2 can decrease HIV-1 infectivity. While theory predicts that HSV-2 treatment should lower HIV-1 infection probability, my results show that this may not be the case unless a critical dosage of HSV-2 treatment is given to the patient. These results help to explain the conflicting data on HIV-1 infection probability in HSV-2 patients and allow for further insight into the type of treatment HSV-2 positive patients should receive to prevent HIV-1 infection.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/58436
note: Spatial Stochastic Models of HSV-2Lesion Dynamics and Their Link withHIV-1 AcquisitionbyCatherine Margaret McCombe ByrneB.Sc. (Hons), Queen’s University, 2013A THESIS SUBMITTED IN PARTIAL FULFILLMENT OFTHE REQUIREMENTS FOR THE DEGREE OFMASTER OF SCIENCEinTHE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES(Mathematics)THE UNIVERSITY OF BRITISH COLUMBIA(Vancouver)July 2016c© Catherine Margaret McCombe Byrne 2016AbstractPatients with Herpes Simplex Virus-2 (HSV-2) infection face a significantlyhigher risk of contracting HIV-1. This marked increase is thought to bedue not only to herpetic lesions serving as an entry point for the HIV-1 virus, but also to the increase in CD4+ T cells in the human genitalmucosa during HSV-2 lesional events. By creating a stochastic, spatial,mathematical model describing the behaviour of the HSV-2 infection andimmune response in the genital mucosa, I first capture the dynamics thatoccur during the development of an HSV-2 lesion. I then use this model toquantify the risk of acquiring HIV-1 in HSV-2 positive patients upon sexualexposure, and determine whether antivirals meant to control HSV-2 candecrease HIV-1 infectivity. While theory predicts that HSV-2 treatmentshould lower HIV-1 infection probability, my results show that this maynot be the case unless a critical dosage of HSV-2 treatment is given to thepatient. These results help to explain the conflicting data on HIV-1 infectionprobability in HSV-2 patients and allow for further insight into the type oftreatment HSV-2 positive patients should receive to prevent HIV-1 infection.iiPrefaceAll work presented in this dissertation is original, remains unpublished, andhas been independently conducted by the author, Catherine Byrne.iiiTable of ContentsAbstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iiPreface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iiiTable of Contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . ivList of Tables . …
has type: Thesis/Dissertation
date issued: 2016-09
is shown at: 10.14288/1.0305859
language: eng
degree discipline: Mathematics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/58436