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Application of High-Z Nanoparticles to Enhance Current Radiotherapy Treatment Jackson, Nolan; Cecchi, Daniel; Beckham, Wayne; Chithrani, Devika

Abstract

Radiotherapy is an essential component of the treatment regimens for many cancer patients. Despite recent technological advancements to improve dose delivery techniques, the dose escalation required to enhance tumor control is limited due to the inevitable toxicity to the surrounding healthy tissue. Therefore, the local enhancement of dosing in tumor sites can provide the necessary means to improve the treatment modality. In recent years, the emergence of nanotechnology has facilitated a unique opportunity to increase the efficacy of radiotherapy treatment. The application of high-atomic-number (Z) nanoparticles (NPs) can augment the effects of radiotherapy by increasing the sensitivity of cells to radiation. High-Z NPs can inherently act as radiosensitizers as well as serve as targeted delivery vehicles for radiosensitizing agents. In this work, the therapeutic benefits of high-Z NPs as radiosensitizers, such as their tumor-targeting capabilities and their mechanisms of sensitization, are discussed. Preclinical data supporting their application in radiotherapy treatment as well as the status of their clinical translation will be presented.

Item Metadata

Title
Application of High-Z Nanoparticles to Enhance Current Radiotherapy Treatment
Creator
Jackson, Nolan; Cecchi, Daniel; Beckham, Wayne; Chithrani, Devika
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2024-05-22
Description
Radiotherapy is an essential component of the treatment regimens for many cancer patients. Despite recent technological advancements to improve dose delivery techniques, the dose escalation required to enhance tumor control is limited due to the inevitable toxicity to the surrounding healthy tissue. Therefore, the local enhancement of dosing in tumor sites can provide the necessary means to improve the treatment modality. In recent years, the emergence of nanotechnology has facilitated a unique opportunity to increase the efficacy of radiotherapy treatment. The application of high-atomic-number (Z) nanoparticles (NPs) can augment the effects of radiotherapy by increasing the sensitivity of cells to radiation. High-Z NPs can inherently act as radiosensitizers as well as serve as targeted delivery vehicles for radiosensitizing agents. In this work, the therapeutic benefits of high-Z NPs as radiosensitizers, such as their tumor-targeting capabilities and their mechanisms of sensitization, are discussed. Preclinical data supporting their application in radiotherapy treatment as well as the status of their clinical translation will be presented.
Subject
nanoparticle; radiotherapy; radiosensitizer; cancer; chemotherapy; therapeutics
Genre
Article
Type
Text
Language
eng
Date Available
2024-06-18
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0443985
URI
http://hdl.handle.net/2429/88481
Affiliation
Science, Irving K. Barber Faculty of (Okanagan); Non UBC; Computer Science, Mathematics, Physics and Statistics, Department of (Okanagan)
Citation
Molecules 29 (11): 2438 (2024)
Publisher DOI
10.3390/molecules29112438
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0