Application of High-Z Nanoparticles to Enhance Current Radiotherapy Treatment
department or school: Science, Irving K. Barber Faculty of (Okanagan)
department or school: Non UBC
department or school: Computer Science, Mathematics, Physics and Statistics, Department of (Okanagan)
data provider: DSpace
identifier citation: Molecules 29 (11): 2438 (2024)
creator: Jackson, Nolan
creator: Cecchi, Daniel
creator: Beckham, Wayne
creator: Chithrani, Devika
issued: 2024-06-18T18:41:48Z
issued: 2024-05-22
description: Radiotherapy is an essential component of the treatment regimens for many cancer patients. Despite recent technological advancements to improve dose delivery techniques, the dose escalation required to enhance tumor control is limited due to the inevitable toxicity to the surrounding healthy tissue. Therefore, the local enhancement of dosing in tumor sites can provide the necessary means to improve the treatment modality. In recent years, the emergence of nanotechnology has facilitated a unique opportunity to increase the efficacy of radiotherapy treatment. The application of high-atomic-number (Z) nanoparticles (NPs) can augment the effects of radiotherapy by increasing the sensitivity of cells to radiation. High-Z NPs can inherently act as radiosensitizers as well as serve as targeted delivery vehicles for radiosensitizing agents. In this work, the therapeutic benefits of high-Z NPs as radiosensitizers, such as their tumor-targeting capabilities and their mechanisms of sensitization, are discussed. Preclinical data supporting their application in radiotherapy treatment as well as the status of their clinical translation will be presented.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/88481
note: Citation: Jackson, N.; Cecchi, D.;Beckham, W.; Chithrani, D.B.Application of High-Z Nanoparticlesto Enhance Current RadiotherapyTreatment. Molecules 2024, 29, 2438.https://doi.org/10.3390/molecules29112438Academic Editor: Josef JampilekReceived: 29 April 2024Revised: 19 May 2024Accepted: 20 May 2024Published: 22 May 2024Copyright: © 2024 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).moleculesReviewApplication of High-Z Nanoparticles to Enhance CurrentRadiotherapy TreatmentNolan Jackson 1, Daniel Cecchi 1, Wayne Beckham 1,2 and Devika B. Chithrani 1,3,4,5,*1 Department of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2, Canada2 British Columbia Cancer-Victoria, Victoria, BC V8R 6V5, Canada3 Centre for Advanced Materials and Related Technologies, Department of Chemistry, University of Victoria,Victoria, BC V8P 5C2, Canada4 Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada5 Department of Computer Science, Mathematics, Physics and Statistics, Okanagan Campus,University of British Columbia, Kelowna, BC V1V 1V7, Canada* Correspondence: devikac@uvic.caAbstract: Radiotherapy is an essential component of the treatment regimens for many cancer patients.Despite recent technological advancements to improve dose delivery techniques, the dose escalationrequired to enhance tumor control is limited due to the inevitable toxicity to the surrounding healthytissue. Therefore, the local enhancement of dosing in tumor sites can provide the necessary means toimprove the treatment modality. In recent years, the emergence of nanotechnology has facilitateda unique opportunity to increase the efficacy of radiotherapy treatment. The application of high-atomic-number (Z) nanoparticles (NPs) can augment the effects of radiotherapy by increasing thesensitivity of ce…
has type: Article
is shown at: 10.14288/1.0443985
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/molecules29112438
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: nanoparticle
subject: radiotherapy
subject: radiosensitizer
subject: cancer
subject: chemotherapy
subject: therapeutics
type: Text
identifier URI: http://hdl.handle.net/2429/88481