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Personalized Ventilation to Multiple Patients Using a Single Ventilator : Description and Proof of Concept Han, Jay S.; Mashari, Azad; Singh, Devin; Dianti, Jose; Goligher, Ewan; Long, Michael; Ng, William; Wasowicz, Marcin; Preiss, David; Vesely, Alex; Kacmarek, Robert; Keshavjee, Shaf; Brochard, Laurent; Fisher, Joseph A.; Slutsky, Arthur S.
Abstract
Objectives: To design and test a ventilator circuit that can be used for ventilation of two or more patients with a single ventilator, while allowing individualization of tidal volume, fractional concentration of oxygen, and positive end-expiratory pressure to each patient, irrespective of the other patient’s respiratory system mechanics. Design: Description and proof of concept studies. Settings: Respiratory therapy laboratory. Subjects: Ventilation of mechanical test lungs. Interventions: Following a previously advocated design, we used components readily available in our hospital to assemble two “bag-ina- box” breathing circuits. Each patient circuit consisted of a flexible bag in a rigid container connected via one-way valve to a test lung, along with an inline positive end-expiratory pressure valve, connected to the ventilator’s expiratory limb. Compressed gas fills the bags during “patient” exhalation. During inspiration, gas from the ventilator, in pressure control mode, enters the containers and displaces gas from the bags to the test lungs. We varied tidal volume, “respiratory system” compliance, and positive end-expiratory pressure in one lung and observed the effect on the tidal volume of the other. Measurements and Main Results: We were able to obtain different tidal volume, dynamic driving pressure, and positive end-expiratory pressure in the two lungs under widely different compliances in both lungs. Complete obstruction, or disconnection at the circuit connection to one test lung, had minimal effect (< 5% on average) on the ventilation to the co-ventilated lung. Conclusions: A secondary circuit “bag-in-the-box” system enables individualized ventilation of two lungs overcoming many of the concerns of ventilating more than one patient with a single ventilator.
Item Metadata
| Title |
Personalized Ventilation to Multiple Patients Using a Single Ventilator : Description and Proof of Concept
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| Creator | |
| Publisher |
Lippincott, Williams & Wilkins
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| Date Issued |
2020
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| Description |
Objectives: To design and test a ventilator circuit that can be used for
ventilation of two or more patients with a single ventilator, while allowing
individualization of tidal volume, fractional concentration of oxygen,
and positive end-expiratory pressure to each patient, irrespective of
the other patient’s respiratory system mechanics. Design: Description and proof of concept studies.
Settings: Respiratory therapy laboratory.
Subjects: Ventilation of mechanical test lungs.
Interventions: Following a previously advocated design, we used
components readily available in our hospital to assemble two “bag-ina-
box” breathing circuits. Each patient circuit consisted of a flexible
bag in a rigid container connected via one-way valve to a test lung,
along with an inline positive end-expiratory pressure valve, connected
to the ventilator’s expiratory limb. Compressed gas fills the bags during
“patient” exhalation. During inspiration, gas from the ventilator,
in pressure control mode, enters the containers and displaces gas
from the bags to the test lungs. We varied tidal volume, “respiratory
system” compliance, and positive end-expiratory pressure in one lung
and observed the effect on the tidal volume of the other.
Measurements and Main Results: We were able to obtain different
tidal volume, dynamic driving pressure, and positive end-expiratory
pressure in the two lungs under widely different compliances in both
lungs. Complete obstruction, or disconnection at the circuit connection
to one test lung, had minimal effect (< 5% on average) on the
ventilation to the co-ventilated lung.
Conclusions: A secondary circuit “bag-in-the-box” system enables
individualized ventilation of two lungs overcoming many of the concerns
of ventilating more than one patient with a single ventilator.
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| Subject | |
| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2021-06-29
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0398734
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| URI | |
| Affiliation | |
| Citation |
Han, J. S., Mashari, A., Singh, D., Dianti, J., Goligher, E., Long, M., . . . Slutsky, A. S. (2020). Personalized ventilation to multiple patients using a single ventilator: Description and proof of concept. Critical Care Explorations, 2(5), e0118-e0118.
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| Publisher DOI |
10.1097/CCE.0000000000000118
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty; Researcher; Postdoctoral
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| Copyright Holder |
Authors
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International