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Rapid Hemostasis in a Sheep Model Using Particles That Propel Thrombin and Tranexamic Acid Baylis, James R.; Finkelstein-Kulka, Andres; Macias-Valle, Luis; Manji, Jamil; Lee, Michael; Levchenko, Elina; Okpaleke, Christopher; Al-Salihi, Salahuddin; Javer, Amin; Kastrup, Christian J.

Abstract

Objectives/Hypothesis: Bleeding during endoscopic sinus surgery and open surgeries can easily obstruct the surgeons’ field of view and increase morbidity and risk of intraoperative complications. Intraoperative bleeding could potentially be addressed by a hemostatic agent that safely disperses itself through the escaping blood. We tested the safety and efficacy of a self-propelling formulation of thrombin and tranexamic acid (SPTT) in stopping bleeding in a paranasal sinus injury and in an open surgical carotid injury sheep model. Study Design: Interventional animal study. Methods: SPTT was tested in the sinonasal space following endoscopic injury to the inferior turbinate of six sheep, and to the common carotid artery following open surgical injury in eight sheep. In the nasal cavity, bleeding time and local inflammation were measured and compared to plain gauze. Following carotid arteriotomy, successful hemostasis and markers of thrombosis and coagulopathy were compared to Floseal. Results: SPTT significantly decreased bleeding times in the sinonasal space compared to plain gauze (mean difference = 3.8 minutes, P = .002). All of the carotid bleeds (100%) were successfully controlled with SPTT after 10 minutes of application under pressure, compared to 25% with Floseal. No adverse events were noted, and there was no evidence of thromboembolism. Conclusions: SPTT significantly reduced bleeding time in a sheep model of surgical sinus bleeding and successfully stopped bleeding following catastrophic carotid artery injury, with no adverse events observed.

Item Metadata

Title
Rapid Hemostasis in a Sheep Model Using Particles That Propel Thrombin and Tranexamic Acid
Creator
Baylis, James R.; Finkelstein-Kulka, Andres; Macias-Valle, Luis; Manji, Jamil; Lee, Michael; Levchenko, Elina; Okpaleke, Christopher; Al-Salihi, Salahuddin; Javer, Amin; Kastrup, Christian J.
Contributor
St. Paul's Hospital (Vancouver, B.C.). Sinus Centre
Date Issued
2016
Description
Objectives/Hypothesis: Bleeding during endoscopic sinus surgery and open surgeries can easily obstruct the surgeons’ field of view and increase morbidity and risk of intraoperative complications. Intraoperative bleeding could potentially be addressed by a hemostatic agent that safely disperses itself through the escaping blood. We tested the safety and efficacy of a self-propelling formulation of thrombin and tranexamic acid (SPTT) in stopping bleeding in a paranasal sinus injury and in an open surgical carotid injury sheep model. Study Design: Interventional animal study. Methods: SPTT was tested in the sinonasal space following endoscopic injury to the inferior turbinate of six sheep, and to the common carotid artery following open surgical injury in eight sheep. In the nasal cavity, bleeding time and local inflammation were measured and compared to plain gauze. Following carotid arteriotomy, successful hemostasis and markers of thrombosis and coagulopathy were compared to Floseal. Results: SPTT significantly decreased bleeding times in the sinonasal space compared to plain gauze (mean difference = 3.8 minutes, P = .002). All of the carotid bleeds (100%) were successfully controlled with SPTT after 10 minutes of application under pressure, compared to 25% with Floseal. No adverse events were noted, and there was no evidence of thromboembolism. Conclusions: SPTT significantly reduced bleeding time in a sheep model of surgical sinus bleeding and successfully stopped bleeding following catastrophic carotid artery injury, with no adverse events observed.
Subject
Functional endoscopic sinus surgery; Hemostat; Intraoperative bleeding; Catastrophic bleeding; Calcium carbonate; Fibrinolysis
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2019-11-13
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0385502
URI
http://hdl.handle.net/2429/72273
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Biochemistry and Molecular Biology, Department of; Occupational Science and Occupational Therapy, Department of; Population and Public Health (SPPH), School of; Surgery, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International