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Mouse germ line mutations due to retrotransposon insertions Gagnier, Liane; Belancio, Victoria P; Mager, Dixie L

Abstract

Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape in mouse contrasts with the situation in human, where their relative contribution as germ line insertional mutagens is much lower. In this focussed review, we provide comprehensive lists of TE-induced mouse mutations, discuss the different TE types involved in these insertional mutations and elaborate on particularly interesting cases. We also discuss differences and similarities between the mutational role of TEs in mice and humans.

Item Metadata

Title
Mouse germ line mutations due to retrotransposon insertions
Creator
Gagnier, Liane; Belancio, Victoria P; Mager, Dixie L
Publisher
BioMed Central
Date Issued
2019-04-13
Description
Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape in mouse contrasts with the situation in human, where their relative contribution as germ line insertional mutagens is much lower. In this focussed review, we provide comprehensive lists of TE-induced mouse mutations, discuss the different TE types involved in these insertional mutations and elaborate on particularly interesting cases. We also discuss differences and similarities between the mutational role of TEs in mice and humans.
Subject
Endogenous retroviruses; Long terminal repeats; Long interspersed elements; Short interspersed elements; Germ line mutation; Inbred mice; Insertional mutagenesis; Transcriptional interference
Genre
Article
Type
Text
Language
eng
Date Available
2019-04-15
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0378229
URI
http://hdl.handle.net/2429/69689
Affiliation
Medicine, Faculty of; Non UBC; Medical Genetics, Department of
Citation
Mobile DNA. 2019 Apr 13;10(1):15
Publisher DOI
10.1186/s13100-019-0157-4
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)