Mouse germ line mutations due to retrotransposon insertions
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Medical Genetics, Department of
data provider: DSpace
identifier citation: Mobile DNA. 2019 Apr 13;10(1):15
rights copyright: The Author(s).
creator: Gagnier, Liane
creator: Belancio, Victoria P
creator: Mager, Dixie L
issued: 2019-04-15T15:58:16Z
issued: 2019-04-13
description: Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape in mouse contrasts with the situation in human, where their relative contribution as germ line insertional mutagens is much lower. In this focussed review, we provide comprehensive lists of TE-induced mouse mutations, discuss the different TE types involved in these insertional mutations and elaborate on particularly interesting cases. We also discuss differences and similarities between the mutational role of TEs in mice and humans.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/69689
note: REVIEW Open AccessMouse germ line mutations due toretrotransposon insertionsLiane Gagnier1, Victoria P. Belancio2 and Dixie L. Mager1*AbstractTransposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutationsreported in inbred mouse strains. This major contribution of TEs to the mutational landscape in mouse contrastswith the situation in human, where their relative contribution as germ line insertional mutagens is much lower. Inthis focussed review, we provide comprehensive lists of TE-induced mouse mutations, discuss the different TE typesinvolved in these insertional mutations and elaborate on particularly interesting cases. We also discuss differencesand similarities between the mutational role of TEs in mice and humans.Keywords: Endogenous retroviruses, Long terminal repeats, Long interspersed elements, Short interspersedelements, Germ line mutation, Inbred mice, Insertional mutagenesis, Transcriptional interferenceBackgroundThe mouse and human genomes harbor similar types ofTEs that have been discussed in many reviews, to whichwe refer the reader for more in depth and general infor-mation [1–9]. In general, both human and mouse con-tain ancient families of DNA transposons, nonecurrently active, which comprise 1–3% of these genomesas well as many families or groups of retrotransposons,which have caused all the TE insertional mutations inthese species. As in humans [4], the mouse genome con-tains active retrotransposon families of long and shortinterspersed repeats (LINEs and SINEs) that can causegerm line mutations via new insertions but, in contrastto humans, the mouse also contains several groups ofretrotranspositionally active endogenous retroviral ele-ments (ERVs) that are responsible for most reported in-sertional mutations.ERVs/LTR retrotransposonsERVs are the result of retroviral infections or retrotran-spositions in the germline. The general structure of anERV is analogous to that of an integrated provirus…
has type: Article
is shown at: 10.14288/1.0378229
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: BioMed Central
publisher DOI: 10.1186/s13100-019-0157-4
rights: Attribution 4.0 International (CC BY 4.0)
rights URI: http://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
subject: Endogenous retroviruses
subject: Long terminal repeats
subject: Long interspersed elements
subject: Short interspersed elements
subject: Germ line mutation
subject: Inbred mice
subject: Insertional mutagenesis
subject: Transcriptional interference
type: Text
identifier URI: http://hdl.handle.net/2429/69689