UBC Faculty Research and Publications

The genetics of smoking in individuals with chronic obstructive pulmonary disease Obeidat, Ma’en; Zhou, Guohai; Li, Xuan; Hansel, Nadia N; Rafaels, Nicholas; Mathias, Rasika; Ruczinski, Ingo; Beaty, Terri H; Barnes, Kathleen C; Paré, Peter D; Sin, Don D

Abstract

Background: Smoking is the principal modifiable environmental risk factor for chronic obstructive pulmonary disease (COPD) which affects 300 million people and is the 3rd leading cause of death worldwide. Most of the genetic studies of smoking have relied on self-reported smoking status which is vulnerable to reporting and recall bias. Using data from the Lung Health Study (LHS), we sought to identify genetic variants associated with quantitative smoking and cessation in individuals with mild to moderate COPD. Methods: The LHS is a longitudinal multicenter study of mild-to-moderate COPD subjects who were all smokers at recruitment. We performed genome-wide association studies (GWASs) for salivary cotinine (n = 4024), exhaled carbon monoxide (eCO) (n = 2854), cigarettes per day (CPD) (n = 2706) and smoking cessation at year 5 follow-up (n = 717 quitters and 2175 smokers). The GWAS analyses were adjusted for age, gender, and genetic principal components. Results: For cotinine levels, SNPs near UGT2B10 gene achieved genome-wide significance (i.e. P 

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