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Preexposure sensitizes rats to the rewarding properties of amphetamine as measured by a progressive ratio paradigm Mendrek, Adrianna
Abstract
Two groups of male Long-Evans rats were compared to determine whether preexposure to amphetamine would enhance the motivation to self-administer the drug under a progressive ratio schedule of reinforcement. In the first phase of the experiment each animal received a single injection of either amphetamine or saline on alternate days for a total of ten injections. Following a 21 day withdrawal period, behavioral sensitization was confirmed by a significant increase in amphetamine-induced stereotypy in the amphetamine-pretreated group, relative to the saline-pretreated group. In the second phase of the study all rats were implanted with chronic jugular catheters and trained to'self-administer amphetamine under a fixed-ratio schedule of reinforcement. The progressive ratio paradigm was then imposed for seven days; amphetamine-pretreated rats attained significantly higher breaking points than saline-pretreated animals. These data indicate that preexposure to psychoactive agents may enhance the motivation of drug self-administration, suggesting augmentation in drug addiction liability.
Item Metadata
Title |
Preexposure sensitizes rats to the rewarding properties of amphetamine as measured by a progressive ratio paradigm
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
1996
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Description |
Two groups of male Long-Evans rats were compared to determine whether preexposure
to amphetamine would enhance the motivation to self-administer the drug
under a progressive ratio schedule of reinforcement. In the first phase of the
experiment each animal received a single injection of either amphetamine or saline
on alternate days for a total of ten injections. Following a 21 day withdrawal
period, behavioral sensitization was confirmed by a significant increase in
amphetamine-induced stereotypy in the amphetamine-pretreated group, relative to
the saline-pretreated group. In the second phase of the study all rats were
implanted with chronic jugular catheters and trained to'self-administer amphetamine
under a fixed-ratio schedule of reinforcement. The progressive ratio paradigm was
then imposed for seven days; amphetamine-pretreated rats attained significantly
higher breaking points than saline-pretreated animals. These data indicate that
preexposure to psychoactive agents may enhance the motivation of drug self-administration,
suggesting augmentation in drug addiction liability.
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Extent |
2179584 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-03-06
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0087582
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
1997-05
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.