Preexposure sensitizes rats to the rewarding properties of amphetamine as measured by a progressive ratio paradigm
department or school: Arts, Faculty of
department or school: Psychology, Department of
data provider: DSpace
degree campus: UBCV
creator: Mendrek, Adrianna
issued: 2009-03-06T20:41:09Z
issued: 1996
related degree: Master of Arts - MA
degree grantor: University of British Columbia
description: Two groups of male Long-Evans rats were compared to determine whether preexposure to amphetamine would enhance the motivation to self-administer the drug under a progressive ratio schedule of reinforcement. In the first phase of the experiment each animal received a single injection of either amphetamine or saline on alternate days for a total of ten injections. Following a 21 day withdrawal period, behavioral sensitization was confirmed by a significant increase in amphetamine-induced stereotypy in the amphetamine-pretreated group, relative to the saline-pretreated group. In the second phase of the study all rats were implanted with chronic jugular catheters and trained to'self-administer amphetamine under a fixed-ratio schedule of reinforcement. The progressive ratio paradigm was then imposed for seven days; amphetamine-pretreated rats attained significantly higher breaking points than saline-pretreated animals. These data indicate that preexposure to psychoactive agents may enhance the motivation of drug self-administration, suggesting augmentation in drug addiction liability.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/5670
extent: 2179584 bytes
format: application/pdf
note: PREEXPOSURE SENSITIZES RATS TO THE REWARDING PROPERTIES OF AMPHETAMINE AS MEASURED BY A PROGRESSIVE RATIO PARADIGM by Adrianna Mendrek B.A., Concordia University, 1994 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF ARTS in THE FACULTY OF GRADUATE STUDIES (Department of Psychology) we accept this thesis as conforming to the required standard THE UNIVERSITY OF BRITISH COLUMBIA December 1996 ® Adrianna Mendrek, 1996 In presenting this thesis in partial fulfilment of the requirements for an advanced degree at the University of British Columbia, I agree that the Library shall make it freely available for reference and study. I further agree that permission for extensive copying of this thesis for scholarly purposes may be granted by the head of my department or by his or her representatives. It is understood that copying or publication of this thesis for financial gain shall not be allowed without my written permission. Department of The University of British Columbia Vancouver, Canada •ate Dec. // /l33( DE-6 (2/88) 11 A B S T R A C T Preexposure Sensitizes Rats to the Rewarding Properties of Amphetamine as Measured by a Progressive Ratio Paradigm Two groups of male Long-Evans rats were compared to determine whether pre-exposure to amphetamine would enhance the motivation to self-administer the drug under a progressive ratio schedule of reinforcement. In the first phase of the experiment each animal received a single injection of either amphetamine or saline on alternate days for a total of ten injections. Following a 21 day withdrawal period, behavioral sensitization was confirmed by a significant increase in amphetamine-induced stereotypy in the amphetamine-pretreated group, relative to the saline-pretreated group. In the second phase of the study all rats were implanted with chronic jugular catheters and trained to'self-administer amphetamine under a fixed-ratio schedule of reinforcement. The progressive ratio paradigm was th…
has type: Thesis/Dissertation
date issued: 1997-05
is shown at: 10.14288/1.0087582
language: eng
degree discipline: Psychology
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/5670