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The effect of parathormone on the mineral content of various vertebrates Rampone, Alfred J.


The effect of parathormone (Lilly) on the total mineral content of bones and muscles (percentage of ash per gram of dry tissue) was used as a measure of hormone activity. Goldfish, frogs, mice, chicks and pigeons were compared. The effect of the parathormone varied with the species. Goldfish showed no response even with massive doses at high temperatures. Frogs, mice and chicks showed a rise in percent bone ash. In chicks an initial rise was followed by a depression. Mice showed the greatest increase in bone ash. Frogs were less responsive than mice but more responsive than chicks. Pigeons showed a distinct softening of the bones. There was no change in muscle ash in any animals except pigeons, which showed a distinct rise. The parathyroid mechanism, whether it acts directly on bones or kidneys, does not seem to operate in aquatic animals.

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