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Some adrenergic and cholinergic factors in the activation of the electroencephalogram in cat

University of British Columbia

A method is reported for the bilateral, synchronous distribution of injected drugs to both sides of the brain simultaneously. Arguments have been made for the advantages of this approach over unilateral intracarotid injections for studying the direct effect of drugs on central synaptic sites. Using this method, preliminary studies have been made of the effects of both adrenergic and cholinergic drugs on the activation of the electroencephalogram in both unanesthetized curarized cats and in cats subjected to mid-brain reticular coagulation. These studies indicate the possible co-existence of both adrenergic and cholinergic components in the mid-brain reticular formation and suggests that anatomically these sites probably are not identical.

Text

2012-01-30

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http://hdl.handle.net/2429/40354

Pharmacology

University of British Columbia

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