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UBC Theses and Dissertations

Caffeine as a hypertensive reagent Crichlow, Eugene Chinloy

Abstract

Caffeine has been shown to induce a transient hypertensive state in Wistar rats. The height to which the blood pressure rises in this caffeine-induced hypertension, and the duration of this hypertensive state was found to be dependent on the concentration of caffeine administered. Caffeine exposed to negatively ionized air was shown to undergo a loss in its pressor activity. This loss in pressor activity was found to be greater when the caffeine was exposed in solution than when it was exposed in the crystalline state. Once the blood pressures of Wistar rats were elevated with injections of caffeine and had again returned to normal levels there were no further rises in blood pressures with the administration of an equal number of injections of this drug.

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