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Coronary artery intimal hyperplasia Harmon, Thomas Peter

Abstract

Intimal hyperplasia in the proximal portion of the right coronary artery was investigated by using longitudinal sections of the artery, to determine the amount of intimal and medial thickness, and the amount of deviation from the normal of the internal elastic lamina. One hundred and one samples in the 0-30 year age range were used and the results correlated with other known information about the individuals. Findings: 1. Intimal thickness increases directly as age increases. 2. There was a sex difference in the 16-30 year age group (males greater than females), but not under 15 years. 3. Intimal thickness increases significantly as the amount of internal elastic lamina change increases. 4. Medial thickness increases significantly with increasing age. 5. Intimal thickness increases significantly as medial thickness, heart mass and body mass increase, and increases at a more rapid rate than any of the three. 6. The amount of elastic lamina change increases significantly with age only between 1 and 30 years. These findings are correlated with the possible factors in the etiology of intimal hyperplasia.

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