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UBC Theses and Dissertations

Some effects of methallibure (I.C.I. 33828) on the stickleback : Gasterosteus aculeatus L. Carew, Barbara Agnes Mary


Treatment of male sticklebacks with methallibure brings about a marked reduction in the level of prespawning aggressiveness. Gametogenesis in the testes of the testes of the treated fish is slowed down so that after 30-38 days of treatment most testes contain spermatozoa and spermatogonia while the testes of the controls are more mature and contain spermatocytes and spermatozoa or spermatozoa only. Forty-nine days of treatment result in testes with spermatogonia, spermatocytes and spermatozoa, control testes are completely mature and contain only spermatozoa. Methallibure causes no significant increase in thyroid epithelial cell height evidence that the I.C.I. compound is not having a direct goitrogenic effect such as is found when fish are immersed in a solution of thiourea. The adenohypophysis of methallibure treated fish contains less basophilic material than that of untreated controls.

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