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The induction of satiety in the rat Ehman, Gerard Kevan

Abstract

A number of peripheral changes possibly involved in the initiation of satiety were examined by injecting various substances into the duodenum. As neither the presence of food nor the pH was found to be important, it was concluded that entry of metabolites into the blood, hormone release, and bulk in the intestine are not significant events in the induction of satiety. It was found, however, that the tonicity of the injected material was important: hypertonic solutions produced a depression in food intake. The duration of the hypertonic effect was about 1½ hours, but this could be shortened considerably by intraperitoneal water injections. Finally, interference with normal digestion by blocking the passage of food and fluids from the stomach to the intestine produced marked and rapid inhibition of intake. These results strongly supported an interpretation for satiety initiation based upon changes in blood tonicity.

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