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Physiological effects of Astragalus miser var. serotinus, (timber milkvetch) on sheep, rats, and mice. Mosher, Gary Alfred

Abstract

Feeding trials were conducted during 1968 and 1969 to study the physiological effects of Astragalus miser var. serotinus, timber milkvetch, (TMV) in sfieep. In Trial I, TMV was collected from Kamloops and Clinton, pelleted and fed to U groups of Dorset Horn wethers at levels of 0, 35, 70 and 100%. The symptoms exhibited by the sheep fed 100% TMV included backward flexion of the fetlock - joints, hind limb paralysis and inco—ordination of movements. The presence of longitudinal ulcers in the intestines was a characteristic lesion observed in the sheep fed 100% TMV. Fatty infiltration and hemorrhages in the liver and kidney were also observed. After the vetch was cut, dried and pelleted, the miserotoxin content dropped from 2.3 - 3.4% to 0.9%. Trial II was carried out under actual grazing conditions near Kamloops. Yearling ewes fed freshly cut TMV showed symptoms similar to those observed in Trial I. However, the symptoms were less severe and could be observed only when the sheep were exerted. The intestinal ulcers were found to be confined to the jejunum. The activity of the serum glutamic – oxaloacetic transaminase was significantly (p

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