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Ultimobranchial origin of calcitonin : a study based on ultimobranchial gland extracts. Kueh, Yankoon


Acid extracts of the ultimobranchial glands of domestic fowl Gallus domestica and the dogfish Squalus suckleyi had a very potent hypocalcemic effect when injected into young rats, while extracts of the corresponding thyroid glands were devoid of such activity. The log. dose response paralleled that obtained with mammalian calcitonin preparations. The data indicate that the ultimobranchial gland, rather than the thyroid, is the source of calcitonin in these species.

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