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UBC Theses and Dissertations

Study of the basement membrane in experimental hyperplasia of the rat thyroid using the electron microscope and stereological analysis Mackenzie, Margaret June


Hyperplasia was induced by physical and chemical means. The resulting goitres were examined by electron microscopy, and the basement membranes were analyzed by stereological methods. The basement membrane in experimental colloid goitre was found to be significantly thinner than its control. A consideration of the course of the various goitres and of the chemical nature of basement membranes leads to the conclusion that the thinning of the basement membrane was the result of stretching.

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