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Toxicological and chemotherapeutic effects of oral cesium chloride in PC-3 and LNCaP prostate Cancer human xenografts

University of British Columbia

Purpose: High pH Therapy is an alternative cancer therapy involving the daily ingestion of concentrated dosages of cesium chloride (CsCl). Although the U.S. Food and Drug Administration has not approved the use of CsCl as a cancer treatment, individuals seeking this therapy need only search the internet to purchase CsCl solutions or tablets. Companies market these CsCl treatments by presenting the most recent CsCl cancer research, the majority of which is outdated and incomplete. The purpose of this study was to assess the therapeutic and toxicological effects of CsCl administration in mice bearing human prostate cancer tumors. Methods: Three CsCl dose titration studies were completed in tumor bearing and nontumor bearing athymic nude mice. All mice were administered either vehicle (controls), 150mg/kg, 300 mg/kg, 600 mg/kg, 800 mg/kg, 1000 mg/kg or 1200mg/kg of CsCl once daily by oral gavage for 30 consecutive days. Body mass was measured daily, food and water consumption were measured every two days, and tumor volume was measured twice weekly. Histopathological analysis was conducted on tissues collected from each of the studies. Serum AST, ALT and creatinine were also measured. Results: Chronic administration of 800mg/kg to 1200mg/kg CsCl significantly reduced PC-3 tumor growth but had no effect on LNCaP tumor growth. In addition, tumor bearing and non-tumor bearing animals receiving these concentrated CsCl dosages (800mg/kg-1200mg/kg) developed bladder crystals and showed an increase in water consumption. An observed loss in body mass and an increased prevalence of postmortem cardiac fibrin clots appeared to be dependent on the xenograft type and concentration of CsCl administered. CsCl did not affect serum AST, ALT and creatinine levels in any of the treatment groups. Conclusions: Although CsCl appears to have some therapeutic benefit in treating the PC-3 prostate cancer model, a number of toxicological effects were also observed linked to its administration, including loss of body mass, increase of water consumption, fibrin clot formation and bladder crystal formation.

Text

2011-02-28

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http://hdl.handle.net/2429/31856

Pharmaceutical Sciences

University of British Columbia

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