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Effects of nonylphenol on stress response in Rainbow Trout, Oncorhynchus mykiss Suto, Akiko

Abstract

During the last few decades, there has been a great concern about the impact of endocrine disrupting chemicals (EDCs) on the health of wildlife and human populations. Nonylphenol, a degraded product of a widely used surfactant, has recently been identified as an estrogenic EDC. A set of experiments were conducted to examine how exposure to three levels (4, 20, and lOOppb) of nonylphenol for certain periods (1-3 weeks) affected physiological function in rainbow trout over time, in terms of their response to an acute stress of air exposure. It was shown that a high level (lOOppb) of nonylphenol suppresses the elevation of plasma Cortisol level in rainbow trout in response to the acute stress of air exposure. In addition, the fish treated with nonylphenol were incapable of reducing their Cortisol levels back to pre-stress levels after 24 hours. The normal response of plasma glucose levels to the stress was observed. Plasma levels of thyroid hormones decreased significantly (p

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