- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Theses and Dissertations /
- Conditioning of ictal and interictal behaviors in rats...
Open Collections
UBC Theses and Dissertations
UBC Theses and Dissertations
Conditioning of ictal and interictal behaviors in rats by amygdala kindling : context as the conditional stimulus Barnes, Steven John
Abstract
We assessed the ability of contextual conditional stimuli that are normally present during the course of kindling to modulate both motor seizures and interictal behavior. Rats received 53 stimulations to the left basolateral amygdala in one context (CS+) and 53 sham stimulations (The lead was attached but no current was delivered.) in another context (CS-), quasirandomly over 54 days. We observed 3 kinds of conditional effects. First, after several stimulations, less ambulatory activity, more freezing, and less rearing reliably occurred in the CS+ context than in the CS- context. Second, after 45 stimulations, all of the rats chose the CS- context over the CS+ context in a conditioned place-preference test. Third, when the rats were finally stimulated in the CS- context, their motor seizures were less severe in several respects: Latencies were longer, motor seizures were shorter, convulsive patterns were of a lower class, and there were fewer falls.
Item Metadata
Title |
Conditioning of ictal and interictal behaviors in rats by amygdala kindling : context as the conditional stimulus
|
Creator | |
Publisher |
University of British Columbia
|
Date Issued |
2000
|
Description |
We assessed the ability of contextual conditional stimuli that are normally present during
the course of kindling to modulate both motor seizures and interictal behavior. Rats received 53
stimulations to the left basolateral amygdala in one context (CS+) and 53 sham stimulations (The
lead was attached but no current was delivered.) in another context (CS-), quasirandomly over 54
days. We observed 3 kinds of conditional effects. First, after several stimulations, less
ambulatory activity, more freezing, and less rearing reliably occurred in the CS+ context than in
the CS- context. Second, after 45 stimulations, all of the rats chose the CS- context over the CS+
context in a conditioned place-preference test. Third, when the rats were finally stimulated in the
CS- context, their motor seizures were less severe in several respects: Latencies were longer,
motor seizures were shorter, convulsive patterns were of a lower class, and there were fewer
falls.
|
Extent |
995724 bytes
|
Genre | |
Type | |
File Format |
application/pdf
|
Language |
eng
|
Date Available |
2009-07-06
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
|
DOI |
10.14288/1.0099438
|
URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
|
Graduation Date |
2000-05
|
Campus | |
Scholarly Level |
Graduate
|
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.