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UBC Theses and Dissertations
Serotonergic drugs and aggression in male firemouth cichlids (cichlasoma meeki) Adams, C.F.
Abstract
The objective of this thesis was to examine the role of brain 5-HT in the regulation of mirror-directed biting in male firemouth cichlids (Cichlasoma meeki). In experiment 1, treatment with the 5-HT synthesis inhibitor DL-p-chlorophenylalanine methyl ester HC1 (PCPA) resulted in a significant increase in mirror-directed biting. In experiment 2, the 5- HTiA agonist (±)-2-dipropylamino-8-hydroxy-l,2,3,4-tetrahydronapthalene HBr (8-OHDPAT) had no effect on aggression. In experiment 3, the 5-HTi A agonist 8-[4-[4-(2- pyrimidinyl)-l-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione HC1 (buspirone) caused a significant reduction in aggression. In experiment 4, the 5-HT2 agonist l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane HC1 (DOI) caused a significant reduction in mirror-directed aggression. These findings demonstrate that brain 5-HT inhibits mirror-directed aggression in male firemouth cichlids.
Item Metadata
| Title |
Serotonergic drugs and aggression in male firemouth cichlids (cichlasoma meeki)
|
| Creator | |
| Publisher |
University of British Columbia
|
| Date Issued |
1995
|
| Description |
The objective of this thesis was to examine the role of brain 5-HT in the regulation of
mirror-directed biting in male firemouth cichlids (Cichlasoma meeki). In experiment 1,
treatment with the 5-HT synthesis inhibitor DL-p-chlorophenylalanine methyl ester HC1
(PCPA) resulted in a significant increase in mirror-directed biting. In experiment 2, the 5-
HTiA agonist (±)-2-dipropylamino-8-hydroxy-l,2,3,4-tetrahydronapthalene HBr (8-OHDPAT)
had no effect on aggression. In experiment 3, the 5-HTi A agonist 8-[4-[4-(2-
pyrimidinyl)-l-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione HC1 (buspirone) caused a
significant reduction in aggression. In experiment 4, the 5-HT2 agonist l-(2,5-dimethoxy-4-
iodophenyl)-2-aminopropane HC1 (DOI) caused a significant reduction in mirror-directed
aggression. These findings demonstrate that brain 5-HT inhibits mirror-directed aggression in
male firemouth cichlids.
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| Extent |
2488913 bytes
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| Genre | |
| Type | |
| File Format |
application/pdf
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| Language |
eng
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| Date Available |
2009-01-28
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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| DOI |
10.14288/1.0099009
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| URI | |
| Degree | |
| Program | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
1995-11
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| Campus | |
| Scholarly Level |
Graduate
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| Aggregated Source Repository |
DSpace
|
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Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.