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UBC Theses and Dissertations

Serotonergic drugs and aggression in male firemouth cichlids (cichlasoma meeki) Adams, C.F.


The objective of this thesis was to examine the role of brain 5-HT in the regulation of mirror-directed biting in male firemouth cichlids (Cichlasoma meeki). In experiment 1, treatment with the 5-HT synthesis inhibitor DL-p-chlorophenylalanine methyl ester HC1 (PCPA) resulted in a significant increase in mirror-directed biting. In experiment 2, the 5- HTiA agonist (±)-2-dipropylamino-8-hydroxy-l,2,3,4-tetrahydronapthalene HBr (8-OHDPAT) had no effect on aggression. In experiment 3, the 5-HTi A agonist 8-[4-[4-(2- pyrimidinyl)-l-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione HC1 (buspirone) caused a significant reduction in aggression. In experiment 4, the 5-HT2 agonist l-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane HC1 (DOI) caused a significant reduction in mirror-directed aggression. These findings demonstrate that brain 5-HT inhibits mirror-directed aggression in male firemouth cichlids.

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