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Magnetic resonance spectroscopy standardization and protocol development Brief, Elana Esther

Abstract

Three separate experiments were conducted in order to develop a protocol for collecting magnetic resonance (MR) data using the MR unit at Vancouver Hospital - UBC Site. These experiments examined solutions at millimolar concentrations of N-Acetyl-Aspartate (NAA), Choline (Clio), Creatine (Cr), and myo-Inositol (mI). The 1H NMR signal from these metabolites varied linearly with their concentration. Various agar gels were made with an NAA solution. The T2 relaxation time of the water signal varied with gel strength. No correlation was seen with the NAA signal T2 time. The scaling factor between the spectroscopy signal and a modified CPMG sequence signal was 2.19 x 10 to the power of 5. Theoretical justification is given for choosing TE and TR times for the MRS protocol. The TE and TR times accurately described the water relaxation as was verified by other techniques. The protocol did not fully characterize the metabolites and the quantification method over-estimated their concentrations.

Item Metadata

Title
Magnetic resonance spectroscopy standardization and protocol development
Creator
Brief, Elana Esther
Publisher
University of British Columbia
Date Issued
1995
Description
Three separate experiments were conducted in order to develop a protocol for collecting magnetic resonance (MR) data using the MR unit at Vancouver Hospital - UBC Site. These experiments examined solutions at millimolar concentrations of N-Acetyl-Aspartate (NAA), Choline (Clio), Creatine (Cr), and myo-Inositol (mI). The 1H NMR signal from these metabolites varied linearly with their concentration. Various agar gels were made with an NAA solution. The T2 relaxation time of the water signal varied with gel strength. No correlation was seen with the NAA signal T2 time. The scaling factor between the spectroscopy signal and a modified CPMG sequence signal was 2.19 x 10 to the power of 5. Theoretical justification is given for choosing TE and TR times for the MRS protocol. The TE and TR times accurately described the water relaxation as was verified by other techniques. The protocol did not fully characterize the metabolites and the quantification method over-estimated their concentrations.
Extent
1964765 bytes
Genre
Thesis/Dissertation
Type
Text
File Format
application/pdf
Language
eng
Date Available
2009-01-31
Provider
Vancouver : University of British Columbia Library
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
DOI
10.14288/1.0098996
URI
http://hdl.handle.net/2429/4023
Degree
Master of Science - MSc
Program
Physics
Affiliation
Science, Faculty of; Physics and Astronomy, Department of
Degree Grantor
University of British Columbia
Graduation Date
1995-11
Campus
UBCV
Scholarly Level
Graduate
Aggregated Source Repository
DSpace

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For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.