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DNA sequence and structure analysis of the Drosophila gene Polyhomeotic Daly, Mark K.


polyhomeotic is a gene of the Polycomb-group required for proper segment determination in Drosophila. Genetic and molecular analysis has shown that ph has a repetetive structure. The DNA sequence presented here shows that ph consists of a direct tandem duplication with very high sequence conservation. Analysis of the sequence has revealed several conserved open reading frames and splice junctions, putative transcriptional promoter and terminator sequences, polyadenylation signals and translational start signals. In addition, the DNA sequence shows that ph contains a zinc finger sequence in each repeat. This suggests that ph may encode a DNA-binding protein.

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