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Regulation of urea synthesis in skate hepatocytes Nener, Jennifer C.

Abstract

Urea synthesis and alanine oxidation were measured in skate (Raja erinacea) hepatocytes incubated with pharmacological doses of four hormones: insulin, glucagon, 1α-OH, and 1,2-dehydro-A. Peptide hormones were used only for short (2.25 hours) incubations, while incubations with steroids were 2.25, 24, or 48 hours. None of the hormones exerted any effects on urea synthesis or alanine oxidation during the shortest incubation period, however after 24 hours 1α-OH caused a significant (p

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