UBC Theses and Dissertations
A comparison of two conventional sedatives-diazepam and droperidol in combination with fentanyl in surgical patients Battrum-Mounts, Deborah E.
One hundred patients who were to have cataract extraction and intraocular lens replacement carried out were randomly assigned to one of two drug groups. The purpose was to compare droperidol/ fentanyl and diazepam/fentanyl for the following effects: central nervous system depression, cardiovascular depression and ability to alleviate anxiety. Patients, psychology observes, and surgeons were not cognizant of others' opionons, nor of assignment of drug treatment group. Experimental design was a between group single treatment design. Psychological testing consisted of State-Trait Anxiety Inventory of Spielberger, Gorsuch and Lushene, and the Sensory/Affect ratio pain descriptors of Gracely, Dubner and McGrath. Opinion of ease of carrying out the surgical procedure was obtained from the surgeon, and opinion of the anaesthetic outcome was obtained from the anaesthetist. While both drug combinations proved to be successful for use as a sedative adjunct to local anaesthetic for this type of surgical procedure some differences were found. Patients found the diazepam/ fentanyl combination provided for a less intense overall procedure, and had little if any recall of the procedure. The surgeons also found the patients less restless in the diazepam/fentanyl group. Anaesthetists rated the level of sedation as equivalent for both groups and found there was not a significant difference between the amount of sedation they observed.
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