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Reducing mitral valve regurgitation through constriction of the annulus Holloway, Daniel Douglas


Introduction Mitral valve regurgitation (MR) is a result of hemodynamic incompetence of the mitral valve. An in-vitro model of MR was developed to investigate type II and type III-b mitral dysfunction. The role of annular constriction in the reduction of MR was investigated. Methods A porcine heart was mounted in the apparatus. Chords were shortened, lengthened, and cut to create a restricted leaflet, a prolapsed leaflet, and a flail leaflet, respectively. A novel annular constriction device was implanted onto the outside surface of the heart. The magnitude of MR was measured for each created lesion at annular constrictions of 10%, 30%, and 50%. The regurgitation flow rate and the change in regurgitation relative to the disease regurgitation rate were calculated. Results Creation of mitral valve lesions produced MR significantly greater than measured baseline values (p

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