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The prediction of adverse maternal outcomes in pre-eclampsia

University of British Columbia

Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility of developing a severity score that can predict adverse maternal outcome. Methods: Design: retrospective chart review of 2 years' PET cases in three tertiary level units. Candidate predictors of adverse maternal outcome: admission gestational age, blood pressure, proteinuria, urine output, SaO₂, seizures, uric acid, creatinine, aspartate transaminase (AST), lactate dehydrogenase, bilirubin, albumin, platelet count, MPV, MPV:platelet ratio, and fibrinogen. Combined adverse maternal outcome: maternal death or one/more of: hepatic failure/haematoma/rupture, Glasgow coma scale <13, stroke, ≥2 seizures, cortical blindness, positive inotrope support, myocardial infarction, infusion of any 3[sup rd] antihypertensive, dialysis, renal transplantation, ≥50% FIO₂ for >lh, intubation, or transfusion of ≥10 units of blood products. Analyses: Women were classified by having achieved the combined adverse maternal outcome or not. Descriptive, parametric and non-parametric test analysis of the predictor variables was performed. The variables with sample size of >400 were selected and univariable logistic regression analysis was done. Variables with univariable p-value <0.25 were selected for multivariable analysis to determine the factors, which influence pre-eclampsia complications. Results: Among 556 women, 58 women (10.4%) developed the outcome (including one death). The most common outcomes were increased oxygen requirements, 3rd infused antihypertensive, and transfusion of >10 units. GA and fibrinogen were lower and TLC, dipstick protein, bilirubin, creatinine, MPV/platelet ratio and AST were greater in those who developed the outcome. Multivariable logistic regression revealed that higher admission GA (odds ratio 0.85), higher dipstick proteinuria (OR 1.53), and higher MPV:platelet (OR 291.0) independently predicted the outcome. Discussion: Several promising markers were identified, which need to be substantiated in a large multi centre study. Such predictors included admission GA, dipstick proteinuria and the MPV:platelet ratio. Bilirubin and fibrinogen appeared to be promising. A prospective study is required to develop a clinical prediction model for PET.

Text

2009-12-11

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http://hdl.handle.net/2429/16403

Reproductive and Developmental Sciences

University of British Columbia

UBCV

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