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UBC Theses and Dissertations
The value of the tuberculin skin test size in predicting the development of tuberculosis in contacts of active cases Morán Mendoza, A. Onofre
Abstract
Objectives: A) to identify the risk factors for tuberculosis (TB) development among contacts of TB cases. B) To determine the tuberculin skin test (TST) size cut-offs that best predict the development of TB for various groups. Methods: A retrospective cohort study of the contacts of active TB cases recorded in the Division of TB control (DTB) of BC from 1990 to 2000 was carried out to identify the development of TB. The prognostic factors for TB development were obtained from the DTB and from several provincial databases. Contacts with HIV or previous TB were excluded. The prognostic factors evaluated were: TST size, age, gender, ethnicity, latent TB infection (LTBI) treatment, type of contact, previous BCG, immunosuppressive conditions and others. Results: Among the 33,146 contacts identified in the DTB, 228 developed TB during the 12- year follow-up period (TB rate 688/100,000) and 82% of TB cases occurred within 2 yrs after exposure. The main prognostic factors for TB development were: malnutrition, no LTBI treatment, TST size ≥5 mm, being a household contact, and young age (all hazard ratios >5; p-values
Item Metadata
| Title |
The value of the tuberculin skin test size in predicting the development of tuberculosis in contacts of active cases
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| Creator | |
| Publisher |
University of British Columbia
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| Date Issued |
2004
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| Description |
Objectives: A) to identify the risk factors for tuberculosis (TB) development among contacts of TB cases. B) To determine the tuberculin skin test (TST) size cut-offs that best predict the development of TB for various groups. Methods: A retrospective cohort study of the contacts of active TB cases recorded in the Division of TB control (DTB) of BC from 1990 to 2000 was carried out to identify the development of TB. The prognostic factors for TB development were obtained from the DTB and from several provincial databases. Contacts with HIV or previous TB were excluded. The prognostic factors evaluated were: TST size, age, gender, ethnicity, latent TB infection (LTBI) treatment, type of contact, previous BCG, immunosuppressive conditions and others. Results: Among the 33,146 contacts identified in the DTB, 228 developed TB during the 12- year follow-up period (TB rate 688/100,000) and 82% of TB cases occurred within 2 yrs after exposure. The main prognostic factors for TB development were: malnutrition, no LTBI treatment, TST size ≥5 mm, being a household contact, and young age (all hazard ratios >5; p-values
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| Extent |
30348422 bytes
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| Genre | |
| Type | |
| File Format |
application/pdf
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| Language |
eng
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| Date Available |
2009-11-30
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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| DOI |
10.14288/1.0091780
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| URI | |
| Degree (Theses) | |
| Program (Theses) | |
| Affiliation | |
| Degree Grantor |
University of British Columbia
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| Graduation Date |
2004-05
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| Campus | |
| Scholarly Level |
Graduate
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| Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.