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The epidemiology and natural history of Hepatitis C infection in a cohort of homosexual men (1982-1998) Craib, Kevin Joseph Patrick
Abstract
Objectives: The objectives of this study were: (1) to estimate the prevalence and incidence of hepatitis C virus (HCV) infection among all gay men residing in Vancouver during the period 1982-98, (2) to identify risk factors for HCV infection and predictors of 'time to HCV seropositivity' in this population, and (3) to determine whether coinfection with HCV adversely influences the natural history of HIV infection in coinfected men. Methods: The Vancouver Lymphadenopathy-AIDS Study (VLAS) has monitored a cohort of homosexual men since November 1982. Serum samples were obtained from 932 men during the period 1982-98, and tested for HCV antibody using EIA1, EIA2, and RIBA. HIV-antibody test results were also available. Data regarding demographic variables, sexual practices, substance use, and history of infectious diseases were obtained from self-administered questionnaires completed during 1982-85. Data regarding HIV-related disease progression were also available including clinical symptoms and signs, physical findings, CD4 cell count, diagnosis of AIDS, and survival. Risk factors for HCV infection were assessed for statistical significance using both cross-sectional comparisons of seropositive and seronegative men and prospective analyses of time to HCV seropositivity. Differences in time to HCV seropositivity, AIDS progression and survival were evaluated by stratified Kaplan-Meier analysis, and tested using the log-rank test. Both logistic regression and Cox proportional hazards regression were used to model the simultaneous effect of several variables on outcomes of interest. All p-values were two-sided. Results: A total of 54 of 932 men (5.8%) tested positive for HCV antibody [95% CI: 4.3%, 7.3%]. HCV prevalence was significantly higher among HIV seropositive men compared to HIV seronegative men (8.8% vs. 2.6%; p
Item Metadata
Title |
The epidemiology and natural history of Hepatitis C infection in a cohort of homosexual men (1982-1998)
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2004
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Description |
Objectives: The objectives of this study were: (1) to estimate the prevalence and
incidence of hepatitis C virus (HCV) infection among all gay men residing in Vancouver
during the period 1982-98, (2) to identify risk factors for HCV infection and predictors
of 'time to HCV seropositivity' in this population, and (3) to determine whether coinfection
with HCV adversely influences the natural history of HIV infection in coinfected
men.
Methods: The Vancouver Lymphadenopathy-AIDS Study (VLAS) has monitored a
cohort of homosexual men since November 1982. Serum samples were obtained from
932 men during the period 1982-98, and tested for HCV antibody using EIA1, EIA2, and
RIBA. HIV-antibody test results were also available. Data regarding demographic
variables, sexual practices, substance use, and history of infectious diseases were
obtained from self-administered questionnaires completed during 1982-85. Data
regarding HIV-related disease progression were also available including clinical
symptoms and signs, physical findings, CD4 cell count, diagnosis of AIDS, and
survival. Risk factors for HCV infection were assessed for statistical significance using
both cross-sectional comparisons of seropositive and seronegative men and prospective
analyses of time to HCV seropositivity. Differences in time to HCV seropositivity,
AIDS progression and survival were evaluated by stratified Kaplan-Meier analysis, and
tested using the log-rank test. Both logistic regression and Cox proportional hazards
regression were used to model the simultaneous effect of several variables on outcomes
of interest. All p-values were two-sided.
Results: A total of 54 of 932 men (5.8%) tested positive for HCV antibody [95% CI: 4.3%,
7.3%]. HCV prevalence was significantly higher among HIV seropositive men
compared to HIV seronegative men (8.8% vs. 2.6%; p
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Extent |
6838683 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-11-27
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0091731
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URI | |
Degree (Theses) | |
Program (Theses) | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2004-05
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.