- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Theses and Dissertations /
- Kainate receptors containing GluR5 subunits contribute...
Open Collections
UBC Theses and Dissertations
UBC Theses and Dissertations
Kainate receptors containing GluR5 subunits contribute to synaptic transmission and long-term potentiation in the hippocampal dentate gyrus Tse, Maric Tsz Lung.
Abstract
It has recently been shown that presynaptic kainate receptors can play a role in synaptic plasticity in the CA3 region of the hippocampus (Bortolotto et al., 1999); however, a role for these receptors in synaptic transmission and synaptic plasticity in other regions of the brain has been difficult to establish. In the present experiments we show that kainate receptors can contribute significantly to synaptic transmission in the dentate gyrus (DG) of the hippocampus, and that furthermore, they appear to play a role in synaptic plasticity in this region. Kainate receptors in the DG appear to be located post-synaptically at excitatory synapses where they can influence synaptic plasticity by alleviating the M g 2+ blockade of NMD A receptors. These results demonstrate that kainate receptors in the DG play a vital post-synaptic role at excitatory synapses, and may contribute to learning and memory processes in this region.
Item Metadata
Title |
Kainate receptors containing GluR5 subunits contribute to synaptic transmission and long-term potentiation in the hippocampal dentate gyrus
|
Creator | |
Publisher |
University of British Columbia
|
Date Issued |
2004
|
Description |
It has recently been shown that presynaptic kainate receptors can play a role in
synaptic plasticity in the CA3 region of the hippocampus (Bortolotto et al., 1999);
however, a role for these receptors in synaptic transmission and synaptic plasticity in
other regions of the brain has been difficult to establish. In the present experiments we
show that kainate receptors can contribute significantly to synaptic transmission in the
dentate gyrus (DG) of the hippocampus, and that furthermore, they appear to play a
role in synaptic plasticity in this region. Kainate receptors in the DG appear to be
located post-synaptically at excitatory synapses where they can influence synaptic
plasticity by alleviating the M g 2+ blockade of NMD A receptors. These results
demonstrate that kainate receptors in the DG play a vital post-synaptic role at
excitatory synapses, and may contribute to learning and memory processes in this
region.
|
Extent |
2598946 bytes
|
Genre | |
Type | |
File Format |
application/pdf
|
Language |
eng
|
Date Available |
2009-11-24
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
|
DOI |
10.14288/1.0091690
|
URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
|
Graduation Date |
2004-05
|
Campus | |
Scholarly Level |
Graduate
|
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.