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Investigation into the mechanism and treatment of atherogenic dyslipidemia in HIV + patients with HIV metabolic syndrome Green, Thomas James

Abstract

The use of highly active combination anti-retroviral therapy is associated with serious metabolic side effects including increased serum triglycerides, decreased HDL cholesterol as well as insulin resistance, peripheral fat loss and gain of abdominal visceral fat. There is concern that anti-retroviral therapy imposes a significant risk of heart disease in the HIV positive population. We hypothesize that development of dyslipidemia in response to anti-retroviral therapy is associated with the presence of specific genetic polymorphisms and may relate to changes in lipoprotein lipase and hepatic lipase levels. We have assessed a number of biochemical and genetic markers in a cohort of HIV+ subjects with dyslipidemia. In our cohort lipoprotein lipase is significantly decreased (36.03 ± 30.17 nmol/min/ml vs. 86.79 ± 63.96 nmol/min/ml, p

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