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UBC Theses and Dissertations

Anti-invasive activity of Bovine colostrum and whey proteins against Salmonella typhimurium Noei, Azita Madadi


Bovine colostrum, non-immunoglobulin G (non-IgG) fraction, obtained after passing colostral whey through a protein G-agarose affinity chromatography column, and selected whey proteins (a-lactalbumin, P-lactoglobulin, lactoferrin and lactoperoxidase) were tested for anti-invasive activity against Salmonella Typhimurium SL 1344 invasion of HeLa cells. Bovine colostrum and non-IgG fraction decreased S. Typhimurium invasion of cultured HeLa cells by 98 and 66% respectively. In an attempt to find the anti-invasive compound(s) in non-IgG fraction of bovine colostral whey, lactoferrin, a-lactalbumin, Blactoglobulin and lactoperoxidase were tested for their effect on HeLa cell invasion by S. Typhimurium. All tested whey proteins except lactoperoxidase, at concentrations up to 10 mg mL⁻¹, significantly (p

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