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UBC Theses and Dissertations
Anti-invasive activity of Bovine colostrum and whey proteins against Salmonella typhimurium Noei, Azita Madadi
Abstract
Bovine colostrum, non-immunoglobulin G (non-IgG) fraction, obtained after passing colostral whey through a protein G-agarose affinity chromatography column, and selected whey proteins (a-lactalbumin, P-lactoglobulin, lactoferrin and lactoperoxidase) were tested for anti-invasive activity against Salmonella Typhimurium SL 1344 invasion of HeLa cells. Bovine colostrum and non-IgG fraction decreased S. Typhimurium invasion of cultured HeLa cells by 98 and 66% respectively. In an attempt to find the anti-invasive compound(s) in non-IgG fraction of bovine colostral whey, lactoferrin, a-lactalbumin, Blactoglobulin and lactoperoxidase were tested for their effect on HeLa cell invasion by S. Typhimurium. All tested whey proteins except lactoperoxidase, at concentrations up to 10 mg mL⁻¹, significantly (p
Item Metadata
| Title | Anti-invasive activity of Bovine colostrum and whey proteins against Salmonella typhimurium |
| Creator | Noei, Azita Madadi |
| Publisher | University of British Columbia |
| Date Issued | 2003 |
| Description |
Bovine colostrum, non-immunoglobulin G (non-IgG) fraction, obtained after passing colostral whey through a protein G-agarose affinity chromatography column, and selected whey proteins (a-lactalbumin, P-lactoglobulin, lactoferrin and lactoperoxidase) were tested for anti-invasive activity against Salmonella Typhimurium SL 1344 invasion of HeLa cells. Bovine colostrum and non-IgG fraction decreased S. Typhimurium invasion of cultured HeLa cells by 98 and 66% respectively. In an attempt to find the anti-invasive compound(s) in non-IgG fraction of bovine colostral whey, lactoferrin, a-lactalbumin, Blactoglobulin and lactoperoxidase were tested for their effect on HeLa cell invasion by S. Typhimurium. All tested whey proteins except lactoperoxidase, at concentrations up to 10 mg mL⁻¹, significantly (p
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| Extent | 10788120 bytes |
| Genre | Thesis/Dissertation |
| Type | Text |
| File Format | application/pdf |
| Language | eng |
| Date Available | 2009-11-12 |
| Provider | Vancouver : University of British Columbia Library |
| Rights | For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use. |
| DOI | 10.14288/1.0091314 |
| URI | |
| Degree | Doctor of Philosophy - PhD |
| Program | Food Science |
| Affiliation | Land and Food Systems, Faculty of |
| Degree Grantor | University of British Columbia |
| Graduation Date | 2003-11 |
| Campus | UBCV |
| Scholarly Level | Graduate |
| Aggregated Source Repository | DSpace |
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For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.