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Maternal leukocyte CD markers, apoptosis and band forms in preeclampsia Fuchisawa, Akiko


INTRODUCTION: Preeclampsia is a pregnancy-specific condition, and it still remains one of the most common causes of maternal mortality in the developed world. Although the exact cause of preeclampsia has not been identified, it is most widely accepted that preeclampsia results from incomplete placentation. Interestingly, normotensive intrauterine growth restriction also shows the same defect of placentation. In preeclampsia, the maternal syndrome develops from a number of alternative pathways leading to uteroplacental mismatch and, consequently, the release of endothelium-activating factors. This research is focused on neutrophil activation and the hypothesis for this research was that maternal neutrophils and monocytes are inappropriately activated in preeclampsia but not in normotensive intrauterine growth restriction. METHODS: This was a prospective controlled cohort study in a tertiary center. Subjects consisted of cases: women with early-onset preeclampsia (

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