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Phytochemistry and biological activities of selected Colombian medicinal plants López Sarria, Andrés Augusto
Abstract
This thesis deals with the search for antibiotic compounds in medicinal plants traditionally used in the treatment of skin morbid conditions by First Nations People in Colombia. The plant collection was carried out in four culturally and geographically different regions of Colombia. Twenty-four chemical plant extracts were screened against different Gram positive and Gram negative bacteria, yeast and viruses. The plant extract from Piper lanceaefolium exhibited good activity against the yeast Candida albicans and the one from Iryanthera megistophylla displayed very good activity against herpes simplex virus and Staphylococcus aureus MS (methicillin-sensitive). Four compounds, not described in the literature, were isolated and further characterised from Piper lanceaefolium. Phytochemical analyses of Iryanthera megistophylla carried out by Dr. Dong Sheng Ming led to the isolation of two new compounds and seven known compounds. Amongst the known compounds a flavolignan, iryantherin K, presented potent activity against Staphylococcus aureus MS (methicillinsensitive) and more importantly against Staphylococcus aureus MR (methicillinresistant). Iryantherin K and its stereoisomer iryantherin L also exhibited good inhibition of the Candida albicans secreted aspartic protease, which is a virulent factor in Candida infections. The therapeutic potential that is offered by iryantherin K justifies a further toxicological and pharmacological assessment in animal models.
Item Metadata
Title |
Phytochemistry and biological activities of selected Colombian medicinal plants
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2003
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Description |
This thesis deals with the search for antibiotic compounds in medicinal plants traditionally used in the treatment of skin morbid conditions by First Nations People in Colombia. The plant collection was carried out in four culturally and geographically different regions of Colombia. Twenty-four chemical plant extracts were screened against different Gram positive and Gram negative bacteria, yeast and viruses. The plant extract from Piper lanceaefolium exhibited good activity against the yeast Candida albicans and the one from Iryanthera megistophylla displayed very good activity against herpes simplex virus and Staphylococcus aureus MS (methicillin-sensitive). Four compounds, not described in the literature, were isolated and further characterised from Piper lanceaefolium. Phytochemical analyses of Iryanthera megistophylla carried out by Dr. Dong Sheng Ming led to the isolation of two new compounds and seven known compounds. Amongst the known compounds a flavolignan, iryantherin K, presented potent activity against Staphylococcus aureus MS (methicillinsensitive) and more importantly against Staphylococcus aureus MR (methicillinresistant). Iryantherin K and its stereoisomer iryantherin L also exhibited good inhibition of the Candida albicans secreted aspartic protease, which is a virulent factor in Candida infections. The therapeutic potential that is offered by iryantherin K justifies a further toxicological and pharmacological assessment in animal models.
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Extent |
7671400 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-11-16
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0091221
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2003-05
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.