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UBC Theses and Dissertations
Development and validation of a disease specific quality of life questionnaire for potentially curable patients with carcinoma of the esophagus Clifton, Joanne Caroline
Abstract
Objectives: To develop, pre-test and validate a disease specific quality of life (QOL) questionnaire (EQOL) for potentially curable patients with esophageal carcinoma, for use with the EORTC QLQ-C30 questionnaire, assessing treatment associated quality of life. Methods: Questionnaire development Patients enrolled in three centres. Literature reviews, patients, family members, and health care professionals generated 195 items - symptoms (55); emotions (53); physical functioning (17); activities of daily living (ADL) (48); leisure/social (22). 38 patients identified items of importance and assigned importance ratings on a five point Likert scale. Impact scores were calculated as frequency times mean item importance. Item impact scores less than 20/100 were excluded. Pearson's Correlation Co-efficients compared domains with the MOS SF-20. Fifteen items remained in the EQOL. Questionnaire validation Sixty-five patients enrolled in four centres. EORTC QLQ-C30, EQOL, MOS SF-36 and a Global Rating of Change Questionnaire were completed at baseline, one week, one month, three months, and six months after treatment began. Reliability was assessed comparing mean baseline and one week scores. Responsiveness was assessed between mean scores of changed and unchanged patients, and a responsiveness index was calculated. The MOS SF-36 was used for criterion validity. Construct validity included four a priori predictions. Results: Mean scores between baseline and one week for unchanged patients were not significant (p>0.05), except in the physical function domain (p=0.025). Symptom, physical function and social domains were responsive to change at all time intervals (p
Item Metadata
Title |
Development and validation of a disease specific quality of life questionnaire for potentially curable patients with carcinoma of the esophagus
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2003
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Description |
Objectives: To develop, pre-test and validate a disease specific quality of life (QOL) questionnaire (EQOL) for potentially curable patients with esophageal carcinoma, for use with the EORTC QLQ-C30 questionnaire, assessing treatment associated quality of life. Methods: Questionnaire development Patients enrolled in three centres. Literature reviews, patients, family members, and health care professionals generated 195 items - symptoms (55); emotions (53); physical functioning (17); activities of daily living (ADL) (48); leisure/social (22). 38 patients identified items of importance and assigned importance ratings on a five point Likert scale. Impact scores were calculated as frequency times mean item importance. Item impact scores less than 20/100 were excluded. Pearson's Correlation Co-efficients compared domains with the MOS SF-20. Fifteen items remained in the EQOL. Questionnaire validation Sixty-five patients enrolled in four centres. EORTC QLQ-C30, EQOL, MOS SF-36 and a Global Rating of Change Questionnaire were completed at baseline, one week, one month, three months, and six months after treatment began. Reliability was assessed comparing mean baseline and one week scores. Responsiveness was assessed between mean scores of changed and unchanged patients, and a responsiveness index was calculated. The MOS SF-36 was used for criterion validity. Construct validity included four a priori predictions. Results: Mean scores between baseline and one week for unchanged patients were not significant (p>0.05), except in the physical function domain (p=0.025). Symptom, physical function and social domains were responsive to change at all time intervals (p
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Extent |
15839467 bytes
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Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-10-29
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0091183
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2003-11
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.