UBC Theses and Dissertations
Lumican and fibromodulin in the periodontal ligament : a study in knockout mice Matheson, Stacey L.
Periodontal disease is one of the most common diseases of mankind and may present in otherwise healthy individuals or as part of a medical condition or syndrome. The cause of periodontitis seems to be multifactorial involving both periodontal pathogens and host response. Periodontal disease involves breakdown of collagen fibers of the periodontal ligament, which manifests as increased probing depths and attachment loss around teeth. The integrity of the periodontal ligament, then, seems important in this disease process. Small leucine-rich proteoglycans have been located in the periodontal ligament. These are a family of molecules in the extracellular matrix that, among other things, play a role in collagen fibrillogenesis. This blinded, controlled study investigates the location of lumican and fibromodulin, two class II small leucine-rich proteoglycans, in oral periodontal tissues and their role in the collagen fibrillogenesis using adult mice that are singly or doubly deficient in these two small leucine-rich proteoglycans.
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