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Endotoxin infusion in rats induces apoptotic and survival pathways in the heart McDonald, Treena Elizabeth

Abstract

Inflammatory mediators of sepsis induce apoptosis in many cell lines. We tested the hypothesis that lipopolysacharide (LPS) injection in vivo results in induction of early apoptotic and survival pathways as well as evidence of late-stage apoptosis in the heart. Hearts were collected from control rats and at 6, 12 and 24 hours after LPS injection (4 mg/kg). After LPS injection Bax (early pro-apoptotic) mRNA increased (16% at 24 hours, p

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