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UBC Theses and Dissertations

Sexual behaviour enhancing effects of melatonin Brotto, Lori Anne


Anecdotal reports suggest that melatonin enhances libido in men. However, controlled trials remain to be published for any species. Accordingly, male rats were chronically treated for 12 weeks with melatonin via the drinking water. All aspects of sexual activity, including measures of both libido and potency, were significantly facilitated. In addition, there was a consistent, progressive reduction in the frequency of wet dog shake behaviour, suggestive of a temporal decrement in serotonergic receptor activity. To date, this is the first empirical report of a facilitatory role for melatonin in sexual behaviour.

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