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UBC Theses and Dissertations
Regulation of steroid hormone production by the human granulosa-luteal cells Khorasheh, Shideh
Abstract
as an activin-binding protein. However, follistatin may also have direct actions on granulosa cells which are independent of its activin-binding activity. Follistatin stimulated basal progesterone and estradiol production; however, this stimulatory effect of follistatin on basal levels of steroid hormones was not present in all of the experiments. Follistatin did not affect hCG-stimulated estradiol and progesterone production by human granulosa cells. The biochemical pathways that lead to the formation ofthe Ang II/III exists in the human ovary. The effects of Ang II and Ang III with regard to steroid production in the ovary were investigated. Ang III but not Ang II inhibited hCG-stimulated progesterone production. On the other hand, Ang II stimulated basal estradiol levels while Ang III had no effect on basal or hCG-induced estradiol production. Taken together, these results suggest that Ang II and Ang III may promote follicular maturation in the human ovary by enhancing basal estradiol production from granulosa cells and preventing premature luteinization. In summary, the results from this study showed that local ovarian substances play a role in modulating the steroid hormone production by the granulosa cells. It is anticipated that future studies may allow for a better understanding of the coordinated action of many local substances involved in regulating steroid hormone production in the human ovary.
Item Metadata
Title |
Regulation of steroid hormone production by the human granulosa-luteal cells
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
1993
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Description |
as an activin-binding protein. However, follistatin may also have direct actions on
granulosa cells which are independent of its activin-binding activity. Follistatin
stimulated basal progesterone and estradiol production; however, this stimulatory
effect of follistatin on basal levels of steroid hormones was not present in all of the
experiments. Follistatin did not affect hCG-stimulated estradiol and progesterone
production by human granulosa cells.
The biochemical pathways that lead to the formation ofthe Ang II/III exists in the
human ovary. The effects of Ang II and Ang III with regard to steroid production in
the ovary were investigated. Ang III but not Ang II inhibited hCG-stimulated
progesterone production. On the other hand, Ang II stimulated basal estradiol levels
while Ang III had no effect on basal or hCG-induced estradiol production. Taken
together, these results suggest that Ang II and Ang III may promote follicular
maturation in the human ovary by enhancing basal estradiol production from
granulosa cells and preventing premature luteinization.
In summary, the results from this study showed that local ovarian substances
play a role in modulating the steroid hormone production by the granulosa cells. It
is anticipated that future studies may allow for a better understanding of the
coordinated action of many local substances involved in regulating steroid hormone
production in the human ovary.
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Extent |
3661738 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-02-21
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0087319
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
1994-05
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.