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Arachidonic acid as a potential intracellular regulator of aromatase activity in human term trophoblast Lin, Show Whei

Abstract

The potential role of arachidonic acid as an intracellular regulator of aromatase activity of human term trophoblast was investigated in short term (3 h) incubations. Melittin, a known activator of phospholipase A₂,suppressed the aromatase activity of physically dissociated trophoblast cells in a dose-dependent manner. Indomethacin (10⁻⁴M), a cyclooxygenase inhibitor of arachidonic acid metabolism, suppressed aromatase activity and potentiated the inhibitory effect of melittin (P

Item Metadata

Title
Arachidonic acid as a potential intracellular regulator of aromatase activity in human term trophoblast
Creator
Lin, Show Whei
Publisher
University of British Columbia
Date Issued
1992
Description
The potential role of arachidonic acid as an intracellular regulator of aromatase activity of human term trophoblast was investigated in short term (3 h) incubations. Melittin, a known activator of phospholipase A₂,suppressed the aromatase activity of physically dissociated trophoblast cells in a dose-dependent manner. Indomethacin (10⁻⁴M), a cyclooxygenase inhibitor of arachidonic acid metabolism, suppressed aromatase activity and potentiated the inhibitory effect of melittin (P
Extent
3850389 bytes
Genre
Thesis/Dissertation
Type
Text
File Format
application/pdf
Language
eng
Date Available
2008-09-16
Provider
Vancouver : University of British Columbia Library
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
DOI
10.14288/1.0086417
URI
http://hdl.handle.net/2429/2029
Degree
Master of Science - MSc
Program
Reproductive and Developmental Sciences
Affiliation
Medicine, Faculty of; Obstetrics and Gynaecology, Department of
Degree Grantor
University of British Columbia
Graduation Date
1992-05
Campus
UBCV
Scholarly Level
Graduate
Aggregated Source Repository
DSpace

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Rights

For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.