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Arachidonic acid as a potential intracellular regulator of aromatase activity in human term trophoblast Lin, Show Whei


The potential role of arachidonic acid as an intracellular regulator of aromatase activity of human term trophoblast was investigated in short term (3 h) incubations. Melittin, a known activator of phospholipase A₂,suppressed the aromatase activity of physically dissociated trophoblast cells in a dose-dependent manner. Indomethacin (10⁻⁴M), a cyclooxygenase inhibitor of arachidonic acid metabolism, suppressed aromatase activity and potentiated the inhibitory effect of melittin (P

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