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Studies of tumor promoters and drug-metabolic enzymes in hamster buccal pouch mucosa Zhang, Dong M.

Abstract

Lack of tumor promoters has been the major obstacle in the use of the hamster buccal pouch mucosa (HBPM) model. Two experiments were designed to investigate the effects of two new mouse skin tumor promoters, okadaic acid (OA) and methyl methanesulfonate (MMS), on HBPM. Short term effects of OA were studied. A single application of10 1.1.g of OA in 0.1 ml of acetone produced marked inflammation as well as an increased mitotic rate (p

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