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UBC Theses and Dissertations

Identification of risk factors associated with cervical Intra-epithelial Neoplasia among women in British Columbia Chew, Danielle Siew Yee


Multiple etiologic factors have been described for invasive cervical cancer. The most important ones being sexual activity and smoking. Less is known regarding the factors predisposing to risk of Cervical Intraepithelial Neoplasia (CIN). The increasing incidence among women prompted a study of this disease in British Columbia in carrying out a case control study to identify the risk factors associated with the disease. Incidentally, that is the main focus of this paper. A case-control design was used with cases and controls identified from the Cytology database of the British Columbia Cancer Agency which contains a complete record of all cervical cytology done in British Columbia. Cases were women with diagnosis of cervical dysplasia or carcinoma in-situ whereas controls were women with no history of cervical abnormality. Estimates of the relative risk together with its 95% confidence interval are obtained from the maximum likelihood estimates of the binary logistic regression models. The important risks factors associated with CIN that have been identified in this study are current cigarette smoking, sexual frequency, number of different lifetime sexual partners, combine usage of both condom and diaphragm and dietary intake of vitamin A.

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