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Functional dynamic spect imaging using a single slow camera rotation Farncombe, Troy
Abstract
Dynamic single photon emission computed tomography (SPECT) is a relatively new imaging method that uses radioactive tracers and tomographic data acquisition techniques in order to quantify temporal changes in regional radiotracer concentrations within a patient. This is important as the rate of change in tracer concentration within an organ often can be related to the functional ability of that organ. In this work, a new method is presented that is able to determine these kinetic rates while using a conventional single or multiple detector SPECT camera, and more importantly, a single, slow camera rotation in the data collection process (herein this reconstruction method will be referred to as dSPECT). This reconstruction method is based on the fact that a temporal change in the activity concentration at a given location can be represented by a linear inequality constraint over time. Two iterative reconstruction algorithms, constrained least squares (CLS) and dynamic expectation maximization (dEM), have been tested using this approach with a variety of computer simulations and phantom experiments. In simulations involving a slow dynamic change of activity, results indicate that the dSPECT reconstruction procedure typically produces kinetic parameter estimates with a 7% error when using projection data acquired with a single 180° rotation of a triple headed SPECT camera system. This error increases to about 15% for data acquired with a dual head system and further increases to about 50% for single detector acquisitions. When simulated with faster dynamic parameters, errors increased slightly to about 8%, 12% and 55% for acquisitions involving triple, dual and single head systems respectively.
Item Metadata
Title |
Functional dynamic spect imaging using a single slow camera rotation
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Creator | |
Publisher |
University of British Columbia
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Date Issued |
2000
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Description |
Dynamic single photon emission computed tomography (SPECT) is a relatively new
imaging method that uses radioactive tracers and tomographic data acquisition techniques
in order to quantify temporal changes in regional radiotracer concentrations within
a patient. This is important as the rate of change in tracer concentration within an organ
often can be related to the functional ability of that organ.
In this work, a new method is presented that is able to determine these kinetic
rates while using a conventional single or multiple detector SPECT camera, and more
importantly, a single, slow camera rotation in the data collection process (herein this
reconstruction method will be referred to as dSPECT). This reconstruction method is
based on the fact that a temporal change in the activity concentration at a given location
can be represented by a linear inequality constraint over time. Two iterative reconstruction
algorithms, constrained least squares (CLS) and dynamic expectation maximization
(dEM), have been tested using this approach with a variety of computer simulations and
phantom experiments.
In simulations involving a slow dynamic change of activity, results indicate that the
dSPECT reconstruction procedure typically produces kinetic parameter estimates with
a 7% error when using projection data acquired with a single 180° rotation of a triple
headed SPECT camera system. This error increases to about 15% for data acquired with
a dual head system and further increases to about 50% for single detector acquisitions.
When simulated with faster dynamic parameters, errors increased slightly to about 8%,
12% and 55% for acquisitions involving triple, dual and single head systems respectively.
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Extent |
27330709 bytes
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Genre | |
Type | |
File Format |
application/pdf
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Language |
eng
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Date Available |
2009-07-20
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Provider |
Vancouver : University of British Columbia Library
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Rights |
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
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DOI |
10.14288/1.0085703
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URI | |
Degree | |
Program | |
Affiliation | |
Degree Grantor |
University of British Columbia
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Graduation Date |
2000-11
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Campus | |
Scholarly Level |
Graduate
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.