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UBC Theses and Dissertations

Bioelectric potentials and active transfer in frog skin Ko, Howard


The vibrating probe voltmeter for the measurement of bioelectric potentials by Bluh and Scott has been used in an improved form for measurements of frog skin potential differences. In good agreement with earlier findings the observed frog skin potential differences were found to be of the order of 100 millivolts, and the polarity such that the inside of the skin was positive relative to the outside. Bioelectric potential measurements were made during the influx of sodium chloride and amino acids in aqueous solutions into frog skin in either direction. Characteristic potential changes were observed for different substances and opposite directions of flux, and have been used to demonstrate the asymmetry of frog skin permeability. Transfer mechanisms for sodium chloride and amino acids have been advanced from the standpoint of the assumption that an electrical field exists in the frog skin membrane.

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